There are many naturally occurring fatty acids present inside the body if a human. Just like most of them, Palmitoylethanolamide in short called PEA is a naturally occurring endogenous fatty acid amide which belongs to the class of nuclear factor agonists. They are also produced in animals as well as plants and are used for multiple purposes, mainly related to relieving pain.
They bind themselves to a nuclear receptor and through which it exerts various biological effects, some related to chronic inflammation and some to pain. Some of the primary reports also show the anti-nociceptive, anti-inflammatory, neuroprotective, and anticonvulsant properties.
Clinical use and research related to PEA
There has been a long going research on animal models to know more about the effects of PEA on body physiology. The pharmacologicalpain therapy offers several alternative methods to battle pain, but even after the available solutions, the management remains unsatisfactory as no therapy is completely effective while dealing with pain relief.
Palmitoylethanolamide has been proven to be an effective pain relief method with minimum side effects as compared to other drugs that develop a dependency and interfere with the normal physiology of the human body. Due to this, the use of PEA for dealing with chronic inflammation and severe pain is considered to be a good strategy and is expanding day by day.
According to the early researches, PEA is widely considered as an agonist of cannabinoid type two receptor, commonly written as CB2,and with further research, it is shown that PEA has minimum or very low affinity with this particular receptor. Even after having a low affinity for it, PEA somehow indirectly activates the CB2 as well as the cannabinoid receptor type 1.
Ways in which PEA affect
PEA develops its effect by its several interactions following different pathways.
- It reduces the activation and recruitment of mast cells at the site of nerve injury along with the release of different chemicals like the release of pro-inflammatory mediators from these affected cells;all of this is done with the help of peroxisome proliferator-activated receptor-alpha.
- It inhibits the microglia activation and recruitment of mast cellsinside of the spinal cord, after the body suffers any kind of peripheral nerve injury, as well as following spinal neuroinflammation or other spinal cord injuries.
Some of the studies show how PEA has a positive effect like pyrroloquinoline quinone disodium salt and can be used in a multitude of chronic pain conditions. Some of its essential functioning and effects are:
- It is proven to be beneficial and has a positive effect considered for the treatment of lower back pain that trouble the maximum number of people all over the world.
- It is a good alternative for the management of chronic pain in older patients who are critically ill, and a traditional analgesic may have severe ill effects on their bodies.
- It can be used for the treatment of non-surgical radiculopathies with the use of an ultra micronized formulation of the PEA.